Injections for knee and hip arthritis: steroid, hyaluronic acid and PRP explained

By Mr Philip Dobson, Consultant Orthopaedic Surgeon specialising in knee and hip conditions in Newcastle (Newcastle Hospitals NHS and Nuffield Health).

Joint injections can be an effective treatment for patients with knee or hip arthritis who continue to experience pain despite physiotherapy, activity modification, and simple pain relief.

While injections do not reverse arthritis, they can reduce pain, improve function, and help patients remain active. In many cases, they can also help delay the need for hip or knee replacement surgery.

There are several different types of injections available. Each works in a different way, and the most appropriate option depends on the severity of arthritis, symptoms, and individual patient goals.

Corticosteroid injections

Corticosteroid injections have been used safely and effectively for many decades. They work by reducing inflammation within the joint.

These injections can be particularly helpful when arthritis symptoms suddenly worsen or become more painful.

The main advantage of steroid injections is that they can provide relatively rapid pain relief. However, this relief is often temporary, typically lasting from a few weeks to a few months. Steroid injections do not improve the underlying joint environment, and repeated frequent use is not recommended.

For this reason, steroid injections are generally used for short-term symptom control rather than long-term management.

Hyaluronic acid injections

Hyaluronic acid is a naturally occurring component of healthy joint fluid, where it helps lubricate and cushion the joint.

In osteoarthritis, the quality of the joint fluid changes, and hyaluronic acid injections aim to improve lubrication and reduce mechanical irritation within the joint.

Some patients experience improvement in pain and function following hyaluronic acid injections. However, the degree of benefit varies between individuals, and symptom relief is usually temporary.

Hyaluronic acid injections may be helpful in selected patients, particularly in earlier stages of arthritis.

Platelet-rich plasma (PRP)

Platelet-rich plasma (PRP) is an increasingly used treatment for osteoarthritis and is supported by a substantial and growing body of clinical research.

PRP is prepared from a small sample of your own blood. The platelets contain natural growth factors that help regulate inflammation and support the joint environment.

Unlike treatments that primarily suppress inflammation, PRP works by influencing the biological processes within the joint. This approach aims to improve symptoms by supporting the overall joint environment rather than simply providing temporary relief.

Multiple clinical studies have shown that PRP can improve pain and function in patients with knee and hip osteoarthritis, particularly in mild to moderate disease. It is widely used internationally as part of modern joint preservation strategies.

PRP has an excellent safety profile, as it uses your body’s own natural biological material.

As with all treatments, individual responses vary, but many patients experience meaningful and longer-lasting symptom improvement.

Other newer injection treatments

You may also read about newer synthetic gel injections designed to improve joint cushioning.

These treatments are relatively recent developments, and research into their long-term effectiveness is ongoing. While early results are encouraging, they do not yet have the same depth of clinical evidence or long-term experience as more established treatments such as PRP.

When considering any injection treatment, it is important to choose an option supported by strong clinical research and appropriate for your individual condition.

Which injection is right for you?

The most appropriate injection depends on several factors, including:

  • The severity of arthritis
  • Your symptoms and functional limitations
  • Your age and activity level
  • Previous treatments
  • Your personal goals

Injection treatments are often most effective when combined with physiotherapy, strengthening exercises, and activity modification.

For many patients, they can significantly improve symptoms and help maintain an active lifestyle.

When should injections be considered?

Injection treatments may be appropriate if:

  • Pain persists despite physiotherapy and simple measures
  • Symptoms interfere with walking, exercise, or sleep
  • You wish to explore non-surgical treatment options
  • Surgery is not yet necessary

They can form an important part of managing arthritis and, in some cases, help delay the need for joint replacement.

Specialist assessment

If you are experiencing persistent knee or hip pain, a specialist assessment can help determine the cause of your symptoms and the most appropriate treatment options.

I offer corticosteroid, hyaluronic acid, and platelet-rich plasma (PRP) injections as part of a comprehensive, individualised approach to treating knee and hip arthritis.

Early treatment can often help reduce pain, improve function, and support long-term joint health.

Mr Philip Dobson, Consultant Orthopaedic Surgeon offers consultations and treatment at Nuffield Health Newcastle